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Browse result for Tyrosine Phosphorylation
※ introduction Tyrosine phosphorylation is the addition of a phosphate (PO43-) group to the amino acid tyrosine on the protein. This transfer of phosphate group from ATP to the amino acid tyrosine on the protein is made possible through the enzyme tyrosine kinase. Tyrosine phosphorylation is considered to be one of the key steps in signal transduction and regulation of enzymatic activity. In tyrosine phosphorylation are important two classes of tyrosine kinase, receptor tyrosine kinase and nonreceptor tyrosine kinase. Receptor tyrosine kinases are type I transmembrane proteins possessing an N-terminal extracellular domain, which can bind activating ligands, a single transmembrane domain, and a C-terminal cytoplasmic domain that includes the catalytic domain. Nonreceptor tyrosine kinases lack a transmembrane domain, most are soluble intracellular proteins, but a subset associate with membranes via a membrane-targeting posttranslational modification, such as an N-terminal myristoyl group, and can act as the catalytic subunit for receptors that lack their own catalytic domain.
Reference
Wiki: Tyrosine Phosphorylation
Reference
Wiki: Tyrosine Phosphorylation
UniProt AC | Entrez ID | Gene Name | Protein Name | Organism |
---|---|---|---|---|
A9UEZ4 | BCR/ABL | BCR/ABL fusion protein isoform X1 | Homo sapiens | |
O00401 | 8976 | WASL | Neural Wiskott-Aldrich syndrome protein | Homo sapiens |
O00767 | 6319 | SCD | Acyl-CoA desaturase -desaturase) | Homo sapiens |
O09000 | 17979 | Ncoa3 | Nuclear receptor coactivator 3 (Thyroid hor | Mus musculus |
O15524 | 8651 | SOCS1 | Suppressor of cytokine signaling 1 | Homo sapiens |
O43353 | 8767 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 (RIP- | Homo sapiens |
O60260 | 5071 | PRKN | E3 ubiquitin-protein ligase parkin | Homo sapiens |
O60331 | 23396 | PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma P-5-kinase 1 gamma) | Homo sapiens |
O60674 | 3717 | JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens |
O60716 | 1500 | CTNND1 | Catenin delta-1 ) ) | Homo sapiens |
O75365 | 11156 | PTP4A3 | Protein tyrosine phosphatase type IVA 3 | Homo sapiens |
O95297 | 9019 | MPZL1 | Myelin protein zero-like protein 1 | Homo sapiens |
P00338 | 3939 | LDHA | L-lactate dehydrogenase A chain | Homo sapiens |
P00519 | 25 | ABL1 | Tyrosine-protein kinase ABL1 | Homo sapiens |
P00533 | 1956 | EGFR | Epidermal growth factor receptor | Homo sapiens |
P01106 | 4609 | MYC | Myc proto-oncogene protein | Homo sapiens |
P02549 | 6708 | SPTA1 | Spectrin alpha chain, erythrocytic 1 | Homo sapiens |
P02786 | 7037 | TFRC | Transferrin receptor protein 1 [Cleaved into: Transferrin receptor protein 1, serum form ] | Homo sapiens |
P03372 | 2099 | ESR1 | Estrogen receptor | Homo sapiens |
P04049 | 5894 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens |
P04626 | 2064 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens |
P05067 | 351 | APP | Amyloid-beta A4 protein [Cleaved into: N-APP; Soluble APP-a | Homo sapiens |
P06213 | 3643 | INSR | Insulin receptor [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Homo sapiens |
P06241 | 2534 | FYN | Tyrosine-protein kinase Fyn | Homo sapiens |
P06400 | 5925 | RB1 | Retinoblastoma-associated protein | Homo sapiens |
P06493 | 983 | CDK1 | Cyclin-dependent kinase 1 | Homo sapiens |
P06576 | 506 | ATP5B | ATP synthase subunit beta, mitochondrial | Homo sapiens |
P07355 | 302 | ANXA2 | Annexin A2 | Homo sapiens |
P07949 | 5979 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Homo sapiens |
P08069 | 3480 | IGF1R | Insulin-like growth factor 1 receptor [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Homo sapiens |
P08581 | 4233 | MET | Hepatocyte growth factor receptor | Homo sapiens |
P09914 | 3434 | IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 | Homo sapiens |
P0DP23 | 801 | CALM1 | Calmodulin-1 | Homo sapiens |
P10275 | 367 | AR | Androgen receptor | Homo sapiens |
P10636 | 4137 | MAPT | Microtubule-associated protein tau | Homo sapiens |
P10721 | 3815 | KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens |
P11274 | 613 | BCR | Breakpoint cluster region protein | Homo sapiens |
P12004 | 5111 | PCNA | Proliferating cell nuclear antigen | Homo sapiens |
P12931 | 6714 | SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens |
P14923 | 3728 | JUP | Junction plakoglobin | Homo sapiens |
P15311 | 7430 | EZR | Ezrin | Homo sapiens |
P15498 | 7409 | VAV1 | Proto-oncogene vav | Homo sapiens |
P16056 | 17295 | Met | Hepatocyte growth factor receptor | Mus musculus |
P16104 | 3014 | H2AFX | Histone H2AX | Homo sapiens |
P16144 | 3691 | ITGB4 | Integrin beta-4 | Homo sapiens |
P16591 | 2241 | FER | Tyrosine-protein kinase Fer | Homo sapiens |
P18669 | 5223 | PGAM1 | Phosphoglycerate mutase 1 | Homo sapiens |
P19174 | 5335 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Homo sapiens |
P19429 | 7137 | TNNI3 | Troponin I, cardiac muscle | Homo sapiens |
P22681 | 867 | CBL | E3 ubiquitin-protein ligase CBL | Homo sapiens |
P24752 | 38 | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Homo sapiens |
P24941 | 1017 | CDK2 | Cyclin-dependent kinase 2 | Homo sapiens |
P25911 | 17096 | Lyn | Tyrosine-protein kinase Lyn | Mus musculus |
P27361 | 5595 | MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens |
P28482 | 5594 | MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens |
P29351 | 15170 | Ptpn6 | Tyrosine-protein phosphatase non-receptor type 6 | Mus musculus |
P29353 | 6464 | SHC1 | SHC-transforming protein 1 | Homo sapiens |
P30304 | 993 | CDC25A | M-phase inducer phosphatase 1 | Homo sapiens |
P30530 | 558 | AXL | Tyrosine-protein kinase receptor UFO | Homo sapiens |
P31749 | 207 | AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens |
P31750 | 11651 | Akt1 | RAC-alpha serine/threonine-protein kinase | Mus musculus |
P31994 | 2213 | FCGR2B | Low affinity immunoglobulin gamma Fc region receptor II-b | Homo sapiens |
P33151 | 1003 | CDH5 | Cadherin-5 | Homo sapiens |
P33993 | 4176 | MCM7 | DNA replication licensing factor MCM7 | Homo sapiens |
P34741 | 6383 | SDC2 | Syndecan-2 | Homo sapiens |
P35222 | 1499 | CTNNB1 | Catenin beta-1 | Homo sapiens |
P35235 | 19247 | Ptpn11 | Tyrosine-protein phosphatase non-receptor type 11 | Mus musculus |
P35436 | 14811 | Grin2a | Glutamate receptor ionotropic, NMDA 2A | Mus musculus |
P35580 | 4628 | MYH10 | Myosin-10 | Homo sapiens |
P36888 | 2322 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens |
P37231 | 5468 | PPARG | Peroxisome proliferator-activated receptor gamma | Homo sapiens |
P37840 | 6622 | SNCA | Alpha-synuclein | Homo sapiens |
P39689 | 12575 | Cdkn1a | Cyclin-dependent kinase inhibitor 1 | Mus musculus |
P40763 | 6774 | STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens |
P41350 | 25404 | Cav1 | Caveolin-1 | Rattus norvegicus |
P42224 | 6772 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | Homo sapiens |
P42225 | 20846 | Stat1 | Signal transducer and activator of transcription 1 | Mus musculus |
P42226 | 6778 | STAT6 | Signal transducer and activator of transcription 6 | Homo sapiens |
P42227 | 20848 | Stat3 | Signal transducer and activator of transcription 3 | Mus musculus |
P42229 | 6776 | STAT5A | Signal transducer and activator of transcription 5A | Homo sapiens |
P46108 | 1398 | CRK | Adapter molecule crk | Homo sapiens |
P46527 | 1027 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | Homo sapiens |
P48025 | 20963 | Syk | Tyrosine-protein kinase SYK | Mus musculus |
P48356 | 16847 | Lepr | Leptin receptor | Mus musculus |
P48357 | 3953 | LEPR | Leptin receptor | Homo sapiens |
P49023 | 5829 | PXN | Paxillin | Homo sapiens |
P49185 | 116554 | Mapk8 | Mitogen-activated protein kinase 8 | Rattus norvegicus |
P49789 | 2272 | FHIT | Bis-triphosphatase | Homo sapiens |
P49841 | 2932 | GSK3B | Glycogen synthase kinase-3 beta | Homo sapiens |
P50281 | 4323 | MMP14 | Matrix metalloproteinase-14 | Homo sapiens |
P51692 | 6777 | STAT5B | Signal transducer and activator of transcription 5B | Homo sapiens |
P52333 | 3718 | JAK3 | Tyrosine-protein kinase JAK3 | Homo sapiens |
P52735 | 7410 | VAV2 | Guanine nucleotide exchange factor VAV2 | Homo sapiens |
P53350 | 5347 | PLK1 | Serine/threonine-protein kinase PLK1 | Homo sapiens |
P53778 | 6300 | MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens |
P56945 | 9564 | BCAR1 | Breast cancer anti-estrogen resistance protein 1 | Homo sapiens |
P60484 | 5728 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | Homo sapiens |
P63330 | 19052 | Ppp2ca | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | Mus musculus |
P67775 | 5515 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | Homo sapiens |
P68431 | 8350 | HIST1H3A | Histone H3.1 | Homo sapiens |
P98083 | 20416 | Shc1 | SHC-transforming protein 1 | Mus musculus |
Q00495 | 307403 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Rattus norvegicus |
Q00535 | 1020 | CDK5 | Cyclin-dependent-like kinase 5 | Homo sapiens |
Q01097 | 14812 | Grin2b | Glutamate receptor ionotropic, NMDA 2B | Mus musculus |
Q01279 | 13649 | Egfr | Epidermal growth factor receptor | Mus musculus |
Q03135 | 857 | CAV1 | Caveolin-1 | Homo sapiens |
Q05397 | 5747 | PTK2 | Focal adhesion kinase 1 | Homo sapiens |
Q05655 | 5580 | PRKCD | Protein kinase C delta type [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (SD | Homo sapiens |
Q06124 | 5781 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Homo sapiens |
Q07912 | 10188 | TNK2 | Activated CDC42 kinase 1 | Homo sapiens |
Q13769 | 8563 | THOC5 | THO complex subunit 5 homolog | Homo sapiens |
Q14185 | 1793 | DOCK1 | Dedicator of cytokinesis protein 1 | Homo sapiens |
Q14247 | 2017 | CTTN | Src substrate cortactin | Homo sapiens |
Q14289 | 2185 | PTK2B | Protein-tyrosine kinase 2-beta (Proline-rich tyrosine | Homo sapiens |
Q14790 | 841 | CASP8 | Caspase-8 [Cleaved into: Casp | Homo sapiens |
Q15654 | 7205 | TRIP6 | Thyroid receptor-interacting protein 6 | Homo sapiens |
Q16539 | 1432 | MAPK14 | Mitogen-activated protein kinase 14 (Mitogen-activated protein kinase p38 a | Homo sapiens |
Q16881 | 7296 | TXNRD1 | Thioredoxin reductase 1, cytoplasmic (Thior | Homo sapiens |
Q60598 | 13043 | Cttn | Src substrate cortactin | Mus musculus |
Q62165 | 13138 | Dag1 | Dystroglycan [Cleaved into: Alpha-dystroglycan ; Beta-dystroglycan ] | Mus musculus |
Q6X936 | 310695 | Kirrel1 | Kin of IRRE-like protein 1 | Rattus norvegicus |
Q8BFP9 | 228026 | Pdk1 | [Pyruvate dehydrogenase ] kinase isozyme 1, mitochondrial | Mus musculus |
Q8NE01 | 26505 | CNNM3 | Metal transporter CNNM3 | Homo sapiens |
Q8VI36 | 19303 | Pxn | Paxillin | Mus musculus |
Q91V14 | 57138 | Slc12a5 | Solute carrier family 12 member 5 | Mus musculus |
Q92529 | 53358 | SHC3 | SHC-transforming protein 3 | Homo sapiens |
Q92731 | 2100 | ESR2 | Estrogen receptor beta | Homo sapiens |
Q96BF3 | 126259 | TMIGD2 | Transmembrane and immunoglobulin domain-containing protein 2 | Homo sapiens |
Q96GP6 | 91179 | SCARF2 | Scavenger receptor class F member 2 | Homo sapiens |
Q99613 | 8663 | EIF3C | Eukaryotic translation initiation factor 3 subunit C | Homo sapiens |
Q9BR39 | 57158 | JPH2 | Junctophilin-2 | Homo sapiens |
Q9BSJ8 | 23344 | ESYT1 | Extended synaptotagmin-1 | Homo sapiens |
Q9BXH1 | 27113 | BBC3 | Bcl-2-binding component 3 | Homo sapiens |
Q9C0H9 | 80725 | SRCIN1 | SRC kinase signaling inhibitor 1 | Homo sapiens |
Q9H792 | 79834 | PEAK1 | Pseudopodium-enriched atypical kinase 1 | Homo sapiens |
Q9NPH5 | 50507 | NOX4 | NADPH oxidase 4 H-oxidase) | Homo sapiens |
Q9NZC7 | 51741 | WWOX | WW domain-containing oxidoreductase | Homo sapiens |
Q9R044 | 64563 | Nphs1 | Nephrin | Rattus norvegicus |
Q9UKV8 | 27161 | AGO2 | Protein argonaute-2 | Homo sapiens |
Q9UM73 | 238 | ALK | ALK tyrosine kinase receptor | Homo sapiens |
Q9Z1X1 | 29579 | Esyt1 | Extended synaptotagmin-1 | Rattus norvegicus |